Shinya HAGIHARA

Personal History

2003.3 Ph.D, Department of Synthetic Chemistry and Biological Chemistry, Graduate School of Engineering, Kyoto University (Prof. Isao SAITO)




2001.4 JSPS Research Fellow (DC2)

2003.4 Postdoctral fellow, Department of Synthetic Chemistry and Biological Chemistry, Graduate School of Engineering, Kyoto University (Prof. Kazuhiko Nakatani)

2003.6 Postdoctoral fellow, RIKEN (Prof. Yukishige Ito)

2007.4 Postdoctoral fellow, Department of Organic Chemistry, University of Geneva (Prof. Stefan Matile)

2008.4 Assistant Professor, Institute of Multidisciplinary Research for Advanced Materials, Tohoku University (Prof. Fumi Nagatsugi)

2013.4 Associate Professor, Institute of Transformative Bio-Molecules, Nagoya University (Prof. Kenichiro Itami)

2015.12 PRESTO Researcher

2016.7 Associate Professor, Department of Chemistry, Graduate School of Science, Nagoya University (Prof. Kenichiro Itami)

2018.4 Team Leader, Molecular Bioregulation Research Team, RIKEN Center for Sustainable Resource Science

2018.5 (Concurrent appointment) Visiting Professor, Institute of Transformative Bio-Molecules, Nagoya University

Keywords

• Organic Chemistry, Plant Science, Chemical Biology

Awards

• 2019.12 Asian Rising Stars Lectureship, The 18th Asian Chemical Congress “Controlling Plant Hormone Signaling with Synthetic Molecules”
• 2018.7 The 7th Mishima Kaiun Academic Prize
• 2015.9 Lecture Award, The 11th Symposium on Biofunctional Chemistry

Invited and Plenary Lectures

31. “Controlling Plant Hormone Signaling with Synthetic Molecules”
    Asian Chemical Congress, Taipei, 2019.12.12
32. 「フィールドをめざした植物ケミカルバイオロジー」
    第42回日本分子生物学会, 福岡, 2019.12.7
33. 「植物の分子夾雑を制御する」
    CSJ化学フェスタ, 船堀, 2019.10.15
34. 「凸凹戦略によるオーキシンシグナル伝達の制御」
    第15回関西創農薬研究会, 守山, 2019.10.4
35. “Chemical Biology for Dissecting Plant Hormone Signaling”
    2019年度化学系学協会東北大会(山形大会), 山形, 2019.9.22
36. “Dissection of Plant Hormone Signaling with Synthetic Molecules”
    10th RSC-CSJ Joint Symposium–Chemistry for Complex Biological Systems–, Sendai, 2019.9.7
37. 「植物の機能制御をめざしたケミカルバイオロジー」
    化学コミュニケーションのフロンティア若手シンポジウム, 大阪, 2019.6.26
38. “Chemistry-Based Approach to Regulation of Auxin Signaling”
    Tohoku Forum for Creativity Thematic Programs, Plant Stem Cells Workshop: Auxin and plant stem cells, Sendai, 2019.5.20
39. 「オーキシンシグナルの精密制御」
    第60回日本植物生理学会, 名古屋, 2019.3.13
40. 「人工分子を用いた植物の機能制御」
    第一回分子夾雑関東地区シンポジウム, 和光, 2018.12.5
41. 「人工分子を用いた植物の機能制御」
    Pioneering Project: Chemical Probe（生命現象探索分子）第一回合同合宿セミナー, 幕張, 2018.10.13
42. 「人工分子を用いた植物ホルモンシグナルの制御」
    第9回サブウェイセミナー, 早稲田大学, 2018.8.20
43. “Regulation of plant hormone signaling with synthetic molecules”
    第2回植物成長調節物質若手研究会, 八王子, 2018.8.12
44. 「植物ホルモン受容体を介したシグナル伝達の精密制御」
    第18回日本蛋白質科学会年会, 新潟, 2018.6.27
45. “Regulation of plant hormone signaling with synthetic molecules”
    The 1st Chemistry for big biological questions, 東京大学, 2018.6.23
46. “Regulation of plant hormone signaling with synthetic molecules”
    ACS on Campus University of Tokyo & RIKEN, 東京大学, 2018.6.15
47. 「植物ホルモンシグナルの人工的制御」
    日本農芸化学会2018年度大会, 名城大学, 2018.3.16
48. “Small molecules that regulate plant hormone signaling”
    The 2nd International Symposium on Biofunctional Chemistry (ISBC2017), Kyoto, 2017.12.14
49. 「人工分子を用いた植物の機能制御」
    静岡県立大学大学院特別講義, 静岡県立大学, 2017.9.14
50. 「植物ホルモン研究への展開」
    東山新学術異分野融合研究ミーティング, 名古屋大学, 2017.8.22
51. “Synthetic Molecules That Regulate Phytohormone Signaling”
    IoC-IPMB-ITbM Joint Symposium, Academia Sinica, Taipei, 2017.7.13
52. “Controlling Plant Growth and Development with Synthetic Molecules”
    23nd iCeMS International Symposium, Kyoto University, 2017.5.30
53. 「植物機能の制御を目指した分子夾雑の化学」
    日本化学会第９７春季年会　特別企画「分子夾雑の生命化学」, 慶應大学, 2017.3.16
54. “Chemistry-based approach to plant hormone signaling”
    RIKEN CSRS Joint Seminar, RIKEN, 2017.2.23
55. 「植物を制御する合成化学」
    東京大学化学生命工学専攻本郷談話会, 東京大学, 2016.12.17
56. 「有害植物ストライガの制圧に向けた分子戦略」
    第14回糖鎖科学コンソーシアムシンポジウム, 御茶ノ水ソラシティ, 2016.11.2
57. 「植物のしくみを分子で制御する」
    生体機能関連化学部会若手の会, 第28回サマースクール, 蒲郡, 2016.7.15
58. “Plant science and synthetic chemistry integration for regulating strigolactone signaling”
    ICAR 2016, Gyeongju Hwabaek International Convention Center, Korea, 2016.6.29-7.2
59. “Chemical approach toward strigolactone perception in Striga”
    The 1st CSRS-ITbM Joint Workshop, Nagoya University, 2015.1.7
60. “Chemical Approaches Toward Controlling Plant Growth”
    iCeMS-RIKEN Joint Symposium, Kyoto, 2014.2.7
61. “Development of artificial plant growth regulator”
    16^th IRTG Joint Symposium, Munster University, 2013.11.12

Publications

Original papers

2020

52. Development of potent inhibitors for strigolactone receptor DWARF 14
    Masahiko Yoshimura, Sojung F. Kim, Ryosuke Takise, Shuhei Kusano, Sakuya Nakamura, Masanori Izumi, Akiko Yagi, Kenichiro Itami and Shinya Hagihara*
    Chem. Commun. 2020, 56, 14917-14919.
53. A super-sensitive auxin-inducible degron system with an engineered auxin-TIR1 pair
    Kohei Nishimura,* Ryotaro Yamada, Shinya Hagihara, Rie Iwasaki, Naoyuki Uchida, Takumi Kamura, Koji Takahashi, Keiko U. Torii, Tatsuo Fukagawa*
    Nuc. Acid. Res. 2020, 48, e108.
54. Chloroplast Autophagy and Ubiquitination Combine to Manage Oxidative Damage and Starvation Responses
    Yuta Kikuchi, Sakuya Nakamura, Jesse D. Woodson, Hiroyuki Ishida, Qihua Ling, Jun Hidema, R. Paul Jarvis, Shinya Hagihara, Masanori Izumi*
    Plant Physiol. 2020, 183, 1531–1544.
55. Isoform-selective regulation of mammalian cryptochromes
    Simon Miller, You Lee Son, Yoshiki Aikawa, Eri Makino, Yoshiko Nagai, Ashutosh Srivastava, Tsuyoshi Oshima, Akiko Sugiyama, Aya Hara, Kazuhiro Abe, Kunio Hirata, Shinya Oishi, Shinya Hagihara, Ayato Sato, Florence Tama, Kenichiro Itami, Steve A. Kay, Megumi Hatori* and Tsuyoshi Hirota*
    Nat. Chem. Biol. 2020, 16, 676–685.

2019

48. Cell-based screen identifies a new potent and highly selective CK2 inhibitor for modulation of circadian rhythms and cancer cell growth
    Tsuyoshi Oshima, Yoshimi Niwa, Keiko Kuwata, Ashutosh Srivastava, Tomoko Hyoda, Yoshiki Tsuchiya, Megumi Kumagai, Masato Tsuyuguchi, Teruya Tamaru, Akiko Sugiyama, Natsuko Ono, Norjin Zolboot, Yoshiki Aikawa, Shunsuke Oishi, Atsushi Nonami, Fumio Arai, Shinya Hagihara, Junichiro Yamaguchi, Florence Tama, Yuya Kunisaki, Kazuhiro Yagita, Masaaki Ikeda, Takayoshi Kinoshita, Steve A.Kay, Kenichiro Itami* and Tsuyoshi Hirota*
    Sci. Adv. 2019, 5: eaau9060.

2018

47. Discovery of Plant Growth Stimulants by C–H Arylation of 2-Azahypoxanthine
    Hiroyuki Kitano, Jae-Hoon Choi, Ayaka Ueda, Hideto Ito, Shinya Hagihara, Toshiyuki Kan, Hirokazu Kawagishi,* and Kenichiro Itami*
    Org. Lett. 2018, 20, 5684−5687.
48. A Super Strong Engineered Auxin–TIR1 Pair
    Ryotaro Yamada, Keiichiro Murai, Naoyuki Uchida, Koji Takahashi, Rie Iwasaki, Yasuomi Tada, Toshinori Kinoshita, Kenichiro Itami, Keiko U. Torii,* and Shinya Hagihara*
    Plant Cell Physiol. 2018, 59, 1538–1544.
49. Synthesis and Properties of 2′-OMe-RNAs Modified with Cross-Linkable 7-Deazaguanosine Derivatives
    Ken Yamada, Yusuke Abe, Hirotaka Murase, Yuta Ida, Shinya Hagihara, and Fumi Nagatsugi*
    J. Org. Chem. 2018, 83, 8851-8862.
50. Rapid and reversible root growth inhibition by TIR1 auxin signalling
    Matyáš Fendrych, Maria Akhmanova, Jack Merrin1, Matouš Glanc, Shinya Hagihara, Koji Takahashi, Naoyuki Uchida, Keiko U. Torii and Jiří Friml*
    Nat. Plants 2018, 4, 453–459.
51. The dynamics of strigolactone perception in Striga hermonthica : a working hypothesis
    Yuichiro Tsuchiya,* Masahiko Yoshimura, Shinya Hagihara
    J. Exp. Botany 2018, 69, 2281–2290. DOI: 10.1093/jxb/ery061
52. Discovery of shoot branching regulator targeting strigolactone re-ceptor DWARF14
    Masahiko Yoshimura, Ayato Sato, Keiko Kuwata, Yoshiaki Inukai, Toshinori Kinoshita, Kenichiro Itami, Yuichiro Tsuchiya, and Shinya Hagihara
    ACS Central Science, 2018, 4, 230-234. DOI: 10.1021/acscentsci.7b00554
53. Chemical hijacking of auxin signaling with an engineered auxin-TIR1 pair
    Naoyuki Uchida, Koji Takahashi, Rie Iwasaki, Ryotaro Yamada, Masahiko Yoshimura, Takaho A. Endo, Seisuke Kimura, Hua Zhang, Mika Nomoto, Yasuomi Tada, Toshinori Kinoshita, Kenichiro Itami, Shinya Hagihara*, and Keiko U. Torii*
    Nat. Chem. Biol., 2018, 14, 299-307. DOI: 10.1038/nCHeMBIO.2555

2017

40. Discovery of Synthetic Small Molecules that Enhance the Number of Stomata: C-H Functionalization Chemistry for Plant Biology
    Asraa Ziadi, Nayuki Uchida, Hiroe Kato, Rina Hisamatsu, Ayato Sato, Shinya Hagihara, Kenichiro Itami and Keiko U. Torii
    Chem. Commun., 2017, 53, 9632-9635.
41. Key Structural Elements of Unsymmetrical Cyanine Dyes for Highly Sensitive Fluorescence Turn-On DNA Probes
    Kakishi Uno, Taeko Sasaki, Nagisa Sugimoto, Hideto Ito, Taishi Nishihara, Shinya Hagihara, Tetsuya Higashiyama, Narie Sasaki, Yoshikatsu Sato, Kenichito Itami
    Chem. Asian. J. 2017, 12, 233-238.

2016

38. High-throughput Assay for Quantification of Aminoglycoside–Ribosome Interaction
    Shun Yamashita, Dominik Bergmann, Ayato Sato, Mika Nomoto, Yasuomi Tada, Hans-Ulrich Humpf, Kenichiro Itami and Shinya Hagihara
    Chem. Lett. 2016, 45, 1048-1050. DOI:10.1246/cl.160508

2015

37. Making Dimethylamino a Transformable Directing Group by Nickel‐Catalyzed C-N Borylation
    Hua Zhang, Shinya Hagihara, and Kenichiro Itami
    Chem. Eur. J. 2015 21, 16796-16800. DOI: 10.1002/chem.201503596
38. Probing strigolactone receptors in Striga hermonthica with fluorescence
    Yuichiro Tsuchiya, Masahiko Yoshimura, Yoshikatsu Sato, Keiko Kuwata, Shigeo Toh, Duncan Holbrook-Smith, Hua Zhang, Peter McCourt, Kenichiro Itami, Toshinori Kinoshita, Shinya Hagihara
    Science 2015, 349, 864-868. DOI: 10.1126/science.aab3831.
39. Aromatic C-H Borylation by Nickel Catalysis
    Hua Zhang, Shinya Hagihara, Kenichiro Itami
    Chem. Lett. 2015, 44 (6), 779-781. DOI: 10.1246/cl.150154.

2014

34. Development of the crosslinking reactions to RNA triggered by oxidation
    Kusano, S.; Haruyama, T.; Ishiyama, S.; Hagihara, S.; Nagatsugi, F.,
    Chem. Commun. 2014, 50 (30), 3951-3954. DOI: 10.1039/c3cc49463b.

2013

33. The Crosslink Formation of 2′-OMe Oligonucleotide Containing 2-Amino-6-vinylpurine Protects mRNA from miRNA-Mediated Silencing
    Shinya Hagihara, Wei-Chen Lin, Shuhei Kusano, Xiao-guang Chao, Tsuneaki Hori, Shuhei Imoto, and Fumi Nagatsugi
    Chembiochem 2013, 14 (12), 1427-1429. DOI: 10.1002/cbic.201300382.
    
34. Synthesis of peptide-conjugated light-driven molecular motors and evaluation of their DNA-binding properties
    Fumi Nagatsugi, Yousuke Takahashi, Maiko Kobayashi, Shunsuke Kuwahara, Suhei Kusano, Tomoko Chikuni, Shinya Hagihara, Nobuyuki Harada.
    Molecular Biosystems 2013, 9 (5), 969-973. DOI: 10.1039/c2mb25520k.

2012

31. Synthesis of 6-amino-2-vinylpurine derivatives for cross-linking and evaluation of the reactivity
    Suhei Kusano, Tomoya Sakuraba, Shinya Hagihara, Fumi Nagatsugi
    Bioorg. Med. Chem. Lett., 2012, 22, 6957-6961. DOI: 10.1016/j.bmcl.2012.08.122.
32. Production of truncated protein by the crosslink formation of mRNA with 2′-OMe oligoribonucleotide containing 2-amino-6-vinylpurine
    Shinya Hagihara, Tsuneaki Hori, Suhei Kusano, Shuhei Imoto, WeiChen Lin, XiaoGuang Chao, Fumi Nagatsugi
    Bioorg. Med. Chem. Lett., 2012, 22, 3870-3872.
33. Dependency of the cross-linking reactivity with 2-amino-6-vinylpurine on the neighboring bases
    Fumi Nagatsugi, Shinya Hagihara, Shuhei Kusano, Xiau-guang Chao
    Nucleic Acid Therapeutics, 2012, 21, 37.

2010

28. Alteration of cross-linking selectivity with the 2′-OMe analogue of 2-amino-6-vinylpurine and evaluation of antisense effects
    Shuhei Imoto, Tsuneaki Hori, Shinya Hagihara, Yousuke Taniguchi, Shigeki Sasaki, Fumi Nagatsugi
    Bioorg. Med. Chem. Lett., 2010, 20, 6121-6124.

2009

27. Hydrazinoanthrylboronic acids as supramolecular exciton-coupled circular dichroism (ECCD) probes for multivalent catechols, particularly epigallocatechin gallate
    Andreas Henning, Shinya Hagihara, Stefan Matile
    Chirality, 2009, 21, 826-835.
28. Systematic synthesis and inhibitory activity of haloacetamidyl oligosaccharide derivatives toward cytoplasmic peptide:N-glycanase
    Ayako Miyazaki, Ichiro Matsuo, Shinya Hagihara, Ayako Kakegawa, Tadashi Suzuki, Yukishige Ito.
    Glycoconj. J., 2009, 26, 133-140.

2008

25. Screening of π-basic naphthalene and anthracene amplifiers for π-acidic synthetic pore sensors
    Shinya Hagihara, Ludovic Gremaud, Guillaume Bollot, Jiri Mareda, Stefan Matile
    J. Am. Chem. Soc., 2008, 130, 4347-4351.
26. Signal amplification by conjugate addition for differential sensing with synthetic pores
    Shinya Hagihara, Hiroyuki Tanaka, Stefan Matile
    Org. Biomol. Chem., 2008, 6, 2259-2262.
27. Boronic acid converters for reactive hydrazide amplifiers: polyphenol sensing in green tea with synthetic pores
    Shinya Hagihara, Hiroyuki Tanaka, Stefan Matile
    J Am. Chem. Soc., 2008, 130, 5656-5657.
28. Artificial tongues and leaves
    Shinya Hagihara, Stefan Matile, Naomi Sakai, et. al.
    Pure Appl. Chem., 2008, 80, 1873-1882.

2007

21. Small-molecule binding to the nonquadruplex form of the human telomeric sequence
    Yuki Goto, Shinya Hagihara, Masaki Hagihara, Kazuhiko Nakatani
    ChemBioChem, 2007, 8, 723-726.
22. Analysis of ER-associated glycoprotein degradation using synthetic glycopeptide probes
    Shinya Hagihara, Kazuhito Goda, Ichiro Matsuo, Yukishige Ito
    Biochem. Biophys. Res. Commun., 2007, 360, 357–362.
23. Fluorescently labeled inhibitor for profiling cytoplasmic peptide:N-glycanase”
    Shinya Hagihara, Ayako Miyazaki, Ichiro Matsuo, Atsushi Tatami, Tadashi Suzuki, Yukishige Ito
    Glycobiology, 2007, 17, 1070-1076.

2006

18. Evaluation of mismatch-binding ligands as inhibitors for Rev–RRE interaction
    Kazuhiko Nakatani, Souta Horie, Yuki Goto, Akio Kobori, Shinya Hagihara
    Bioorg. Med. Chem., 2006, 14, 5384-5388. DOI: 10.1016/j.bmc.2006.03.038.

2005

17. Small-molecule ligand induces nucleotide flipping in (CAG)n trinucleotide repeats
    Kazuhiko Nakatani, Shinya Hagihara, Yuki Goto, Akio Kobori, Masaki Hagihara, Gosuke Hayashi, Motoki Kyo, Makoto Nomura, Masaki Mishima, Chojiro Kojima
    Nature Chemical Biology, 2005, 1, 39-43. DOI: 10.1038/nchembio708.
18. Thermodynamic analysis of interactions between N-linked sugar chains and F-box protein Fbs1
    Shinya Hagihara, Kiichiro Totani, Ichiro Matsuo, Yukishige Ito
    J. Med. Chem., 2005, 48, 3126-3129.
19. Design and synthesis of oligosaccharides that interfere with glycoprotein quality-control systems
    Midori A. Arai, Ichiro Matsuo, Shinya Hagihara, Kiichiro Totani, Jun-ichi Maruyama, Katsuhiko Kitamoto, Yukishige Ito
    ChemBioChem, 2005, 6, 2281-2289.
20. NMR structural analysis of the GG mismatch DNA complexed with naphthyridine dimer
    Makoto Nomura, Shinya Hagihara, Yuki Goto, Kazuhiko Nakatani, Chojiro Kojima
    Nucleic Acids Symp. Ser., 2005, 49, 213-214.
21. Solution structure of a small-molecular ligand complexed with CAG trinucleotide repeat DNA
    Kazuhiko Nakatani, Shinya Hagihara, Yuki Goto, Akio Kobori, Masaki Hagihara, Gosuke Hayashi, Masaki Kyo, Makoto Nomura, Masaki Mishima, Chojiro Kojima
    Nucleic Acids Symp. Ser., 2005, 49, 49-50.

2004

12. Synthesis of fluorine substituted oligosaccharide analogues of monoglucosylated glycan chain, a proposed ligand of lectin-chaperone calreticulin and calnexin
    Yukishige Ito, Shinya Hagihara, Midori A. Arai, Ichiro Matsuo, Maki Takatani
    Glycoconj. J., 2004, 21, 257-266.
13. Synthesis of glycoprotein molecular probes for the analyses of protein quality control system
    Kiichiro Totani, Ichiro Matsuo, Maki Takatani, Midori A. Arai, Shinya Hagihara, Yukishige Ito
    Glycoconj. J., 2004, 21, 69-74. DOI: 10.1023/B:GLYC.0000043751.18027.c1.
14. Detection of guanine–adenine mismatches by surface plasmon resonance sensor carrying naphthyridine–azaquinolone hybrid on the surface
    Shinya Hagihara, Hiroyuki Kumasawa, Yuki Goto, Gosuke Hayashi, Akio Kobori, Isao Saito, Kazuhiko Nakatani
    Nucleic Acids Res., 2004, 32, 278-286.
15. Synthesis of asparagine-linked glycan chains: Toward understanding glycoprotein quality control
    Ichiro Matsuo, Shinya Hagihara, Kiichiro Totani, Toshinori Kashiwagi, Yukishige Ito
    Glycobiology, 2004, 14, 1081-1082.
16. Thermodynamic analysis for the sugar recognition of Fbs1
    Shinya Hagihara, Kiichiro Totani, Ichiro Matsuo, Yukishige Ito
    Glycobiology, 2004, 14, 1096-1096.

2003

7. Induction of a remarkable conformational change in a human telomeric sequence by the binding of naphthyridine dimer: Inhibition of the elongation of a telomeric repeat by telomerase
   Kazuhiko Nakatani, Shinya Hagihara, Shinsuke Sando, Shigeru Sakamoto, Kentaro Yamaguchi, Chihaya Maesawa, Isao Saito
   J. Am. Chem. Soc., 2003, 125, 662–666. DOI: 10.1021/ja027055g.
8. Assessment of the sequence dependency for the binding of 2-aminonaphthyridine to the guanine bulge
   Kazuhiko Nakatani, Souta Horie, Takashi Murase, Shinya Hagihara, Isao Saito
   Bioorg. Med. Chem., 2003, 11, 2347-2353. DOI: 10.1016/S0968-0896(03)00026-9.
9. The binding of naphthyridine tetramer to guanine-rich sequences
   Yuki Goto, Shinya Hagihara, Akio Kobori, Kazuhiko Nakatani, Isao Saito
   Nucleic Acids Res. Suppl., 2003, 3, 133.
10. 2,6-Diaminonaphthyridine derivatives bind to a single nucleotide bulge in DNA
    Hitoshi Suda, Shinya Hagihara, Akio Kobori, Kazuhiko Nakatani, Isao Saito
    Nucleic Acids Research Suppl, 2003, 3, 139.

2002

3. Recognition of DNA mismatch structures
   Shinya Hagihira, Kazuhiko Nakatani, Isao Saito
   Nucleic Acids Res. Suppl., 2002, 2, 127–128.

2001

2. Selective intercalation of charge neutral intercalators into GG and CG steps: Implication of HOMO-LUMO interaction for sequence-selective drug intercalation into DNA
   Kazuhiko Nakatani, Takahiro Matsuno, Kaoru Adachi, Shinya Hagihara, Isao Saito
   J. Am. Chem. Soc., 2001, 123, 5695–5702. DOI: 10.1021/ja003956i.

2000

1. Site selective formation of thymine glycol-containing oligodeoxynucleotides by oxidation with osmium tetroxide and bipyridine-tethered oligonucleotide
   Kazuhiko Nakatani, Shinya Hagihara, Shinsuke Sando, Hiroshi Miyazaki, Kazuhito Tanabe, Isao Saito
   J. Am. Chem. Soc., 2000, 122, 6309–6310. DOI: 10.1021/ja0004478.

Review papers

9. Dissecting plant hormone signaling with synthetic molecules: perspective from the chemists
   Shinya Hagihara, Ryotaro Yamada, Kenichiro Itami, Keiko U. Torii
   Curr. Opin. Plant Biol., 2019, 47, 32-37.
10. Harnessing synthetic chemistry to probe and hijack auxin signaling
    Keiko U. Torii, Shinya Hagihara, Naoyuki Uchida, and Koji Takahashi
    New Phytologist, 2018, 220, 417-424.
11. Merging synthetic chemistry with plant biology and chronobiology for creating transformative molecules
    Kenichiro Itami, Shinya hagihara, Ayato Sato
    Medchem News, 2018, 28, 1-7.
12. 植物ホルモン受容体のケミカルバイオロジー
    『化学と工業』3月号「支部発話題欄」特集記事, 2016
13. ストライガ発芽機構の解明にむけた化学的アプローチ
    日本化学会生体機能関連化学部会ニュースレター No.3, 2015
14. Exploration of oligosaccharide-protein interactions in glycoprotein quality control by synthetic approaches
    Shinya Hagihara, Kiichiro Totani, Yukishige Ito.
    Chem. Rec., 2006, 6, 290-302.
15. Structural approaches to the study of oligosaccharides in glycoprotein quality control
    Yukishige Ito, Shinya Hagihara, Ichiro Matsuo, Kiichiro Totani.
    Curr. Opin. Struct. Biol., 2005, 15, 481-489.
16. 有機合成化学による糖タンパク質糖鎖の機能解明
    戸谷 希一郎, 萩原 伸也, 伊藤 幸成,
    有機合成化学協会誌, 2006, 64, 492-501.
17. “分子シャペロン”
    有機合成化学協会誌, 2006, 64, 573.

Books

1. “タンパク質品質管理の機構解明に向けた糖鎖プローブの合成”
   萩原 伸也, 伊藤 幸成. 『ゲノム化学—医学、分子生物学への応用と展開』化学同人、pp195-202, (2007)