草野　修平Shuhei　KUSANO

Researcher
博士（理学）

草野修平の写真
 
  • 理化学研究所 環境資源科学研究センター 分子生命制御研究チーム 研究員
  • 〒351-0198 埼玉県和光市広沢2番1号 生物科学研究棟 N401
  • E-mail: shuhei.kusano [at] riken.jp ※[at]は@に置き換えてください。

経歴

  • 2009年3月 東北大学理学部化学科 卒業
  • 2011年3月 東北大学理学研究科化学専攻 博士前期課程修了
  • 2014年3月 東北大学理学研究科化学専攻 博士後期課程修了

  • 2013年4月 日本学術振興会特別研究員(DC2)
  • 2014年4月 Yale大学化学科 博士研究員
  • 2014年4月 日本学術振興会特別研究員(PD)
  • 2015年4月 福岡大学理学部化学科 助教
  • 2018年9月 理化学研究所 環境資源科学研究センター 分子生命制御研究チーム 研究員

研究キーワード

  • 有機合成化学、ケミカルバイオロジー

受賞

  • 2023年 13th International Symposium on Bioorganic Chemistry ポスター賞
  • 2017年 塩野義製薬 研究企画賞 (有機合成化学協会)

研究業績

Original papers

  1. Shuhei Kusano*, Keisuke Matsumoto, Osamu Hayashida* "Modular design for fluorophore homodimer probes using diethylentriamine as a common spacer” Org. Biomol. Chem., 2019, 17, 3599-3603.
  2. Shuhei Kusano*, Sae Konishi, Yuji Yamada, Osamu Hayashida* “Synthesis of water-soluble anthracene-appended benzoxaboroles and evaluation of their cis-1,2-diol recognition properties” Org. Biomol. Chem., 2018, 16, 4619-4622.
  3. Shuhei Kusano*, Sae Konishi, Ryuta Ishikawa, Norihiro Sato, Satoshi Kawata, Fumi Nagatsugi, Osamu Hayashida* “Synthesis of Water-Soluble Triazinophanes and Evaluation of Their Molecular Recognition Properties” Eur. J. Org. Chem., 2017, 12, 1618-1623.
  4. Osamu Hayashida*, Kana Nishino, Shuhei Kusano “Synthesis of a Cysteine-linked Cyclophane Dimer Having Two Rhodamine Moieties and its Reduction-Responsive Degradation as Studied by Fluorescence Spectroscopy” J. Incl. Phenom. Macrocycle., 2017, 85, 267-274.
  5. Shuhei Kusano*, Osamu Hayashida* “Development of Tetraphenylethylene-appended Tetraazacyclophanes: the Evaluation of Aggregation-Induced Emission Property and the Application for Biomolecular sensing” Chem. Lett., 2016, 45, 1064-1066.
  6. Osamu Hayashida*, Toshikazu Matsuo, Kazuhiro Nakamura, Shuhei Kusano “Synthesis of Water-Soluble Cyclophane Hexamers Having a Triphenylene Core and Their Enhanced Guest-Binding Behavior” J. Org. Chem., 2016, 81, 4196-4201.
  7. Osamu Hayashida*, Koji Matsushita, Shuhei Kusano “Synthesis and effect of linker length on guest-binding affinity of water-soluble tetraazacyclophane dimers” J. Incl. Phenom. Macrocycle. 2016, 84, 237-243.
  8. Osamu Hayashida*, Miwa Kojima and Shuhei Kusano “Biotinylated Cyclophane: Synthesis, Cyclophane-Avidin Conjugates, and Their Enhanced Guest-Binding Affinity” J. Org. Chem. 2015, 80, 9722-9727.
  9. Matthew E. Diener, Anthony J. Metrano, Shuhei Kusano and Scott J. Miller* “Enantioselective Synthesis of 3-Arylquinazolin-4(3H)-ones via Peptide-Catalyzed Atroposelective Bromination” J. Am. Chem. Sci. 2015, 137, 12369-12377.
  10. Shuhei Kusano, Shogo Ishiyama, Sik Lok Lam, Tsukasa Mashima, Masato Katahira, Kengo Miyamoto, Misako Aida and Fumi Nagatsugi* “Crosslinking Reactions of 4-Amino-6-oxo-2-vinylpyrimidine with Guanine Derivatives and Structural Analysis of the Adducts” Nucleic Acids Res. 2015, 43, 7717-7730.
  11. Shuhei Kusano, Takuya Haruyama, Shogo Ishiyama, Shinya Hagihara, Fumi Nagatsugi* “Development of the Crosslinking Reactions to RNA Triggered by Oxidation” Chem. Commun., 2014, 50, 3951-3954.
  12. Shinya Hagihara, Wei-Chen Lin, Shuhei Kusano, Xiao-guang Chao, Tsuneaki Hori, Shuhei Imoto, Fumi Nagatsugi* “The Crosslink Formation of 2’-OMe Oligonucleotide Containing 2-Amino-6-vinylpurine Protects mRNA from miRNA-mediated Silencing” ChemBioChem, 2013, 14, 1427-1429.
  13. Fumi Nagatsugi, Yusuke Takahashi, Maiko Kobayashi, Shunsuke Kuwahara, Shuhei Kusano, Tomoko Chikuni, Shinya Hagihara and Nobuyuki Harada “Synthesis of Peptide-conjugated Light-driven Molecular Motors and Evaluation of their DNA-binding Properties” Mol. BioSyst., 2013, 9, 969-973.
  14. Shuhei Kusano, Tomoya Sakuraba, Shinya Hagihara and Fumi Nagatsugi “Synthesis of 6-Amino-2-vinylpurine Derivatives for Cross-linking and Evaluation of the Reactivity” Bioorg. Med. Chem. Lett., 2012, 22, 6957-6961.
  15. Shinya Hagihara, Shuhei Kusano, Wei-Chen Li, Xiao-guang Chao, Tsuneaki Hori, Shuhei Imoto,Fumi Nagatsugi “Production of Truncated Protein by the Crosslink Formation of mRNA with 2’-OMe Oligoribonucleotide Containing 2-Amino-6-vinylpurine” Bioorg Med Chem Lett., 2012, 22, 3870-3872.
  16. Shigekazu Ito, Shuehi Kusano, Noboru Morita, Koichi Mikami, Masaaki Yoshifuji. “Ligand Effect of Bulky 2,2-Dialkyl-1-phosphaethenes on Au-catalyzed Cycloisomerization of 1,6-Enynes and Lactonization of Pent-4-ynoic acids” J. Organomet. Chem. 2010, 2, 291–296.
  17. Keiichi Hattori, Shuhei Imoto, Tomoya Hirohama, Shuehi Kusano, Fumi Nagatsugi. “Formation of Highly Selective and Efficient Interstrand Cross-linking to Thymine without Photoirradiation” Chem. Commun. 2009, 45, 6463-6465.