Shuhei KUSANO

Personal History

• 2014.3 Ph.D, Department of Chemistry, Graduate School of Science, Tohoku University


• 2013.4 JSPS Research Fellow (DC2)
• 2014.4 Postdoctral fellow, Department of Chemistry, Yale University
• 2014.4 JSPS Research Fellow (PD)
• 2015.4 Assistant Professor, Department of Chemistry, Graduate School of Science, Fukuoka University
• 2018.9 Research Scientist, Molecular Bioregulation Research Team, RIKEN Center for Sustainable Resource Science

Keywords

• Synthetic Organic Chemistry, Chemical Biology

Awards

• 2023 Poster Award (13th International Symposium on Bioorganic Chemistry, Singapore)
• 2017 Shionogi Award (The Society of Synthetic Organic Chemistry, Japan)

Publications

Original papers

17. Shuhei Kusano*, Keisuke Matsumoto, Osamu Hayashida* "Modular design for fluorophore homodimer probes using diethylentriamine as a common spacer” Org. Biomol. Chem., 2019, 17, 3599-3603.
18. Shuhei Kusano*, Sae Konishi, Yuji Yamada, Osamu Hayashida* “Synthesis of water-soluble anthracene-appended benzoxaboroles and evaluation of their cis-1,2-diol recognition properties” Org. Biomol. Chem., 2018, 16, 4619-4622.
19. Shuhei Kusano*, Sae Konishi, Ryuta Ishikawa, Norihiro Sato, Satoshi Kawata, Fumi Nagatsugi, Osamu Hayashida* “Synthesis of Water-Soluble Triazinophanes and Evaluation of Their Molecular Recognition Properties” Eur. J. Org. Chem., 2017, 12, 1618-1623.
20. Osamu Hayashida*, Kana Nishino, Shuhei Kusano “Synthesis of a Cysteine-linked Cyclophane Dimer Having Two Rhodamine Moieties and its Reduction-Responsive Degradation as Studied by Fluorescence Spectroscopy” J. Incl. Phenom. Macrocycle., 2017, 85, 267-274.
21. Shuhei Kusano*, Osamu Hayashida* “Development of Tetraphenylethylene-appended Tetraazacyclophanes: the Evaluation of Aggregation-Induced Emission Property and the Application for Biomolecular sensing” Chem. Lett., 2016, 45, 1064-1066.
22. Osamu Hayashida*, Toshikazu Matsuo, Kazuhiro Nakamura, Shuhei Kusano “Synthesis of Water-Soluble Cyclophane Hexamers Having a Triphenylene Core and Their Enhanced Guest-Binding Behavior” J. Org. Chem., 2016, 81, 4196-4201.
23. Osamu Hayashida*, Koji Matsushita, Shuhei Kusano “Synthesis and effect of linker length on guest-binding affinity of water-soluble tetraazacyclophane dimers” J. Incl. Phenom. Macrocycle. 2016, 84, 237-243.
24. Osamu Hayashida*, Miwa Kojima and Shuhei Kusano “Biotinylated Cyclophane: Synthesis, Cyclophane-Avidin Conjugates, and Their Enhanced Guest-Binding Affinity” J. Org. Chem. 2015, 80, 9722-9727.
25. Matthew E. Diener, Anthony J. Metrano, Shuhei Kusano and Scott J. Miller* “Enantioselective Synthesis of 3-Arylquinazolin-4(3H)-ones via Peptide-Catalyzed Atroposelective Bromination” J. Am. Chem. Sci. 2015, 137, 12369-12377.
26. Shuhei Kusano, Shogo Ishiyama, Sik Lok Lam, Tsukasa Mashima, Masato Katahira, Kengo Miyamoto, Misako Aida and Fumi Nagatsugi* “Crosslinking Reactions of 4-Amino-6-oxo-2-vinylpyrimidine with Guanine Derivatives and Structural Analysis of the Adducts” Nucleic Acids Res. 2015, 43, 7717-7730.
27. Shuhei Kusano, Takuya Haruyama, Shogo Ishiyama, Shinya Hagihara, Fumi Nagatsugi* “Development of the Crosslinking Reactions to RNA Triggered by Oxidation” Chem. Commun., 2014, 50, 3951-3954.
28. Shinya Hagihara, Wei-Chen Lin, Shuhei Kusano, Xiao-guang Chao, Tsuneaki Hori, Shuhei Imoto, Fumi Nagatsugi* “The Crosslink Formation of 2’-OMe Oligonucleotide Containing 2-Amino-6-vinylpurine Protects mRNA from miRNA-mediated Silencing” ChemBioChem, 2013, 14, 1427-1429.
29. Fumi Nagatsugi, Yusuke Takahashi, Maiko Kobayashi, Shunsuke Kuwahara, Shuhei Kusano, Tomoko Chikuni, Shinya Hagihara and Nobuyuki Harada “Synthesis of Peptide-conjugated Light-driven Molecular Motors and Evaluation of their DNA-binding Properties” Mol. BioSyst., 2013, 9, 969-973.
30. Shuhei Kusano, Tomoya Sakuraba, Shinya Hagihara and Fumi Nagatsugi “Synthesis of 6-Amino-2-vinylpurine Derivatives for Cross-linking and Evaluation of the Reactivity” Bioorg. Med. Chem. Lett., 2012, 22, 6957-6961.
31. Shinya Hagihara, Shuhei Kusano, Wei-Chen Li, Xiao-guang Chao, Tsuneaki Hori, Shuhei Imoto,Fumi Nagatsugi “Production of Truncated Protein by the Crosslink Formation of mRNA with 2’-OMe Oligoribonucleotide Containing 2-Amino-6-vinylpurine” Bioorg Med Chem Lett., 2012, 22, 3870-3872.
32. Shigekazu Ito, Shuehi Kusano, Noboru Morita, Koichi Mikami, Masaaki Yoshifuji. “Ligand Effect of Bulky 2,2-Dialkyl-1-phosphaethenes on Au-catalyzed Cycloisomerization of 1,6-Enynes and Lactonization of Pent-4-ynoic acids” J. Organomet. Chem. 2010, 2, 291–296.
33. Keiichi Hattori, Shuhei Imoto, Tomoya Hirohama, Shuehi Kusano, Fumi Nagatsugi. “Formation of Highly Selective and Efficient Interstrand Cross-linking to Thymine without Photoirradiation” Chem. Commun. 2009, 45, 6463-6465.