論文・研究成果

PUBLICATIONS

Original papers

2025

Chemical genetics reveals cross-regulation of plant developmental signaling by the immune peptide-receptor pathway

Arvid Herrmann, Krishna Mohan Sepuru, Pengfei Bai, Hitoshi Endo, Ayami Nakagawa, Shuhei Kusano, Asraa Ziadi, Hiroe Kato, Ayato Sato, Jun Liu, Libo Shan, Seisuke Kimura, Kenichiro Itami, Naoyuki Uchida, Shinya Hagihara, Keiko U. Torii*

  • Sci. Adv. 2025, 11, eads3718.

2024

Autophagosome development and chloroplast segmentation occur synchronously for piecemeal degradation of chloroplasts

Masanori Izumi*, Sakuya Nakamura, Kohei Otomo, Hiroyuki Ishida, Jun Hidema, Tomomi Nemoto, Shinya Hagihara

  • eLife 2024, 12, RP93232.

Radicle Growth Regulation of Root Parasitic Plants by Auxin-related Compounds

Kei Tsuzuki, Taiki Suzuki, Michio Kuruma, Kotaro Nishiyama, Ken-ichiro Hayashi, Shinya Hagihara, Yoshiya Seto*

  • Plant Cell Physiol. 2024, 65, 1377-1387.

Cluster effect through the oligomerisation of bioactive disaccharide AMOR on pollen tube capacitation in Torenia fournieri

Akane G. Mizukami, Shuhei Kusano, Shinya Hagihara, Tetsuya Higashiyama

  • RSC Chem. Biol. 2024, 5, 745-750.

Discovery of a Plant 14-3-3 Inhibitor Possessing Isoform Selectivity and In Planta Activity

Kotaro Nishiyama, Yusuke Aihara, Takehiro Suzuki, Koji Takahashi, Toshinori Kinoshita, Naoshi Dohmae, Ayato Sato, Shinya Hagihara*

  • Angew. Chem. Int. Ed. 2024, 63, e202400218.

2023

A Small Compound, HYGIC, Promotes Hypocotyl Growth Through Ectopic Ethylene Response

Mizuki Murao, Rika Kato, Shuhei Kusano, Rina Hisamatsu, Hitoshi Endo, Yasuki Kawabata, Seisuke Kimura, Ayato Sato, Hitoshi Mori, Kenichiro Itami, Keiko U. Torii, Shinya Hagihara, Naoyuki Uchida

  • Plant Cell Physiol. 2023, 64, 1167-1177.

Water-Dispersible Carbon Nano-Test Tubes as a Container for Concentrated DNA Molecules

Y. Hoshikawa, Y. Kanno, H. Tawata, T. Sagae, T. Ishii, S. Imoto, S. Hagihara, T. Wada, F. Nagatsugi, A. Aziz, H. Nishihara, T. Kyotani, T. Itoh

  • Chem. Eur. J. 2023, 29, e202301422.

Identification of a pluripotency-inducing small compound, PLU, that induces callus formation via Heat Shock Protein 90-mediated activation of auxin signaling

Yuki Nakashima, Yuka Kobayashi, Mizuki Murao, Rika Kato, Hitoshi Endo, Asuka Higo, Rie Iwasaki, Mikiko Kojima, Yumiko Takebayashi, Ayato Sato, Mika Nomoto, Hitoshi Sakakibara, Yasuomi Tada, Kenichiro Itami, Seisuke Kimura, Shinya Hagihara, Keiko U. Torii, Naoyuki Uchida*

  • Front. Plant Sci. 2023, 14, 1099587.

Desmethyl type germinone, a specific agonist for the HTL/KAI2 receptor, induces the Arabidopsis seed germination in a gibberellin-independent manner

Shoma Okabe, Kana Kitaoka, Taiki Suzuki, Michio Kuruma, Shinya Hagihara, Shinjiro Yamaguchi, Kosuke Fukui, Yoshiya Seto

  • Biochem. Biophys. Res. Commun. 2023, 649, 110-117.

2022

Development of 1,8-naphthalimide dyes for rapid imaging of subcellular compartments in plants

Shuhei Kusano, Sakuya Nakamura, Masanori Izumi, Shinya Hagihara*

  • Chem. Commun. 2022, 58, 1685-1688. Selected as the outside back cover

2021

Autophagy Contributes to the Quality Control of Leaf Mitochondria

Sakuya Nakamura, Shinya Hagihara, Kohei Otomo, Hiroyuki Ishida, Jun Hidema, Tomomi Nemoto, Masanori Izumi*

  • Plant Cell Physiol. 2021, 62, 229-247.

2020

Development of potent inhibitors for strigolactone receptor DWARF 14

Masahiko Yoshimura, Sojung F. Kim, Ryosuke Takise, Shuhei Kusano, Sakuya Nakamura, Masanori Izumi, Akiko Yagi, Kenichiro Itami and Shinya Hagihara*

  • Chem. Commun. 2020, 56, 14917-14919.

A super-sensitive auxin-inducible degron system with an engineered auxin-TIR1 pair

Kohei Nishimura,* Ryotaro Yamada, Shinya Hagihara, Rie Iwasaki, Naoyuki Uchida, Takumi Kamura, Koji Takahashi, Keiko U. Torii, Tatsuo Fukagawa*

  • Nuc. Acid. Res. 2020, 48, e108.

Chloroplast Autophagy and Ubiquitination Combine to Manage Oxidative Damage and Starvation Responses

Yuta Kikuchi, Sakuya Nakamura, Jesse D. Woodson, Hiroyuki Ishida, Qihua Ling, Jun Hidema, R. Paul Jarvis, Shinya Hagihara, Masanori Izumi*

  • Plant Physiol. 2020, 183, 1531–1544.

Isoform-selective regulation of mammalian cryptochromes

Simon Miller, You Lee Son, Yoshiki Aikawa, Eri Makino, Yoshiko Nagai, Ashutosh Srivastava, Tsuyoshi Oshima, Akiko Sugiyama, Aya Hara, Kazuhiro Abe, Kunio Hirata, Shinya Oishi, Shinya Hagihara, Ayato Sato, Florence Tama, Kenichiro Itami, Steve A. Kay, Megumi Hatori* and Tsuyoshi Hirota*

  • Nat. Chem. Biol. 2020, 16, 676–685.

2019

Cell-based screen identifies a new potent and highly selective CK2 inhibitor for modulation of circadian rhythms and cancer cell growth

Tsuyoshi Oshima, Yoshimi Niwa, Keiko Kuwata, Ashutosh Srivastava, Tomoko Hyoda, Yoshiki Tsuchiya, Megumi Kumagai, Masato Tsuyuguchi, Teruya Tamaru, Akiko Sugiyama, Natsuko Ono, Norjin Zolboot, Yoshiki Aikawa, Shunsuke Oishi, Atsushi Nonami, Fumio Arai, Shinya Hagihara, Junichiro Yamaguchi, Florence Tama, Yuya Kunisaki, Kazuhiro Yagita, Masaaki Ikeda, Takayoshi Kinoshita, Steve A.Kay, Kenichiro Itami* and Tsuyoshi Hirota*

  • Sci. Adv. 2019, 5: eaau9060.

2018

Discovery of Plant Growth Stimulants by C–H Arylation of 2-Azahypoxanthine

Hiroyuki Kitano, Jae-Hoon Choi, Ayaka Ueda, Hideto Ito, Shinya Hagihara, Toshiyuki Kan, Hirokazu Kawagishi,* and Kenichiro Itami*

  • Org. Lett. 2018, 20, 5684−5687.

A Super Strong Engineered Auxin–TIR1 Pair

Ryotaro Yamada, Keiichiro Murai, Naoyuki Uchida, Koji Takahashi, Rie Iwasaki, Yasuomi Tada, Toshinori Kinoshita, Kenichiro Itami, Keiko U. Torii,* and Shinya Hagihara*

  • Plant Cell Physiol. 2018, 59, 1538–1544.

Synthesis and Properties of 2′-OMe-RNAs Modified with Cross-Linkable 7-Deazaguanosine Derivatives

Ken Yamada, Yusuke Abe, Hirotaka Murase, Yuta Ida, Shinya Hagihara, and Fumi Nagatsugi*

  • J. Org. Chem. 2018, 83, 8851-8862.

Rapid and reversible root growth inhibition by TIR1 auxin signalling

Matyáš Fendrych, Maria Akhmanova, Jack Merrin1, Matouš Glanc, Shinya Hagihara, Koji Takahashi, Naoyuki Uchida, Keiko U. Torii and Jiří Friml*

  • Nat. Plants 2018, 4, 453–459.

The dynamics of strigolactone perception in Striga hermonthica : a working hypothesis

Yuichiro Tsuchiya,* Masahiko Yoshimura, Shinya Hagihara

Discovery of shoot branching regulator targeting strigolactone re-ceptor DWARF14

Masahiko Yoshimura, Ayato Sato, Keiko Kuwata, Yoshiaki Inukai, Toshinori Kinoshita, Kenichiro Itami, Yuichiro Tsuchiya, and Shinya Hagihara

  • ACS Central Science, 2018, 4, 230-234. DOI: 10.1021/acscentsci.7b00554

Chemical hijacking of auxin signaling with an engineered auxin-TIR1 pair

Naoyuki Uchida, Koji Takahashi, Rie Iwasaki, Ryotaro Yamada, Masahiko Yoshimura, Takaho A. Endo, Seisuke Kimura, Hua Zhang, Mika Nomoto, Yasuomi Tada, Toshinori Kinoshita, Kenichiro Itami, Shinya Hagihara, and Keiko U. Torii

  • Nat. Chem. Biol., 2018, 14, 299-307. DOI: 10.1038/nCHeMBIO.2555

2017

Discovery of Synthetic Small Molecules that Enhance the Number of Stomata: C-H Functionalization Chemistry for Plant Biology

Asraa Ziadi, Nayuki Uchida, Hiroe Kato, Rina Hisamatsu, Ayato Sato, Shinya Hagihara, Kenichiro Itami and Keiko U. Torii

  • Chem. Commun., 2017, 53, 9632-9635.

Key Structural Elements of Unsymmetrical Cyanine Dyes for Highly Sensitive Fluorescence Turn-On DNA Probes

Kakishi Uno, Taeko Sasaki, Nagisa Sugimoto, Hideto Ito, Taishi Nishihara, Shinya Hagihara, Tetsuya Higashiyama, Narie Sasaki, Yoshikatsu Sato, Kenichito Itami

  • Chem. Asian. J. 2017, 12, 233-238.

2016

High-throughput Assay for Quantification of Aminoglycoside–Ribosome Interaction

Shun Yamashita, Dominik Bergmann, Ayato Sato, Mika Nomoto, Yasuomi Tada, Hans-Ulrich Humpf, Kenichiro Itami and Shinya Hagihara

2015

Making Dimethylamino a Transformable Directing Group by Nickel‐Catalyzed C-N Borylation

Hua Zhang, Shinya Hagihara, and Kenichiro Itami

  • Chem. Eur. J. 2015 21, 16796-16800. DOI: 10.1002/chem.201503596

Probing strigolactone receptors in Striga hermonthica with fluorescence

Yuichiro Tsuchiya, Masahiko Yoshimura, Yoshikatsu Sato, Keiko Kuwata, Shigeo Toh, Duncan Holbrook-Smith, Hua Zhang, Peter McCourt, Kenichiro Itami, Toshinori Kinoshita, Shinya Hagihara

  • Science 2015, 349, 864-868. DOI: 10.1126/science.aab3831.

Aromatic C-H Borylation by Nickel Catalysis

Hua Zhang, Shinya Hagihara, Kenichiro Itami

  • Chem. Lett. 2015, 44 (6), 779-781. DOI: 10.1246/cl.150154.

Review papers

Mitophagy in plants

Sakuya Nakamura, Shinya Hagihara, Masanori Izumi*

  • Biochimica et Biophysica Acta – General Subjects, 2021, 1865, 129916.

葉緑体オートファジーの研究展開：植物を超えた議論の発展を目指して

中村咲耶，泉正範*

  • BSJ-Review, 2021, 12A, 68-77.

オーキシン応答の自在操作を実現する人工ホルモン・受容体ペアの創成

高橋 宏二, 萩原 伸也, 鳥居 啓子, 打田 直行

  • 化学と生物, 2019, 57, 80-87.

Dissecting plant hormone signaling with synthetic molecules: perspective from the chemists

Shinya Hagihara, Ryotaro Yamada, Kenichiro Itami, Keiko U. Torii

  • Curr. Opin. Plant Biol., 2019, 47, 32-37.

Dissecting plant hormone signaling with synthetic molecules: perspective from the chemists

Shinya Hagihara, Ryotaro Yamada, Kenichiro Itami, Keiko U. Torii

  • New Phytologist, 2018, 220, 417-424.

Harnessing synthetic chemistry to probe and hijack auxin signaling

Keiko U. Torii, Shinya Hagihara, Naoyuki Uchida, and Koji Takahashi

  • New Phytologist, 2018, 220, 417-424.

Merging synthetic chemistry with plant biology and chronobiology for creating transformative molecules

Kenichiro Itami, Shinya hagihara, Ayato Sato

  • Medchem News, 2018, 28, 1-7.

植物ホルモン受容体のケミカルバイオロジー

  • 『化学と工業』3月号「支部発話題欄」特集記事, 2016

ストライガ発芽機構の解明にむけた化学的アプローチ

  • 日本化学会生体機能関連化学部会ニュースレター No.3, 2015